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KMID : 1149220070150010145
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Korean Journal of Oriental Medical Prescription
2007 Volume.15 No. 1 p.145 ~ p.161
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Mouse Models of Atopic Dermatitis for Drug Discovery from Medicinal Plants
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Yun Young-Gab
Hwang Joo-Min
Kim Hyoung-Ryool
Jang Seon-Il
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Abstract
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Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers. The clinical phenotype that characterizes AD is the product of interactions between susceptible genes, the environmental factors, defective skin barrier function, and immunologic responses. This review summarizes recent progress in our understanding of the immunopathophysiology of AD and the implications for mouse models of AD in drug discovery from medicinal plants.
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KEYWORD
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Atopic dermatitis, Inflammatory skin disease, Mouse models, Medicinal plants
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